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imaging

IB Clinic

  • Oncology
  • MRI
  • DSC
  • DCE
  • Diffusion
  • Delta T1

IB Clinic is designed to aid trained physicians in advanced image assessment, treatment consideration, and monitoring of therapeutic response. It generates various perfusion and diffusion related parameters, standardized image sets, and image intensity differences.

imaging viewer

Images shown for illustrative purposes only.

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~29% and ~21% improved nodules detection

Riverain's AI suppression technology removes structures that can camouflage cancer and lung disease. 1,2

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Higher inter-reader agreement rates2

Clinical Workflow

IB workflow

For CalanticTM software version 1.0.0, no prior study will be examined.

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    IB DCE

    • Image process: DCE Perfusion Weighted MR Imaging (DCE-MRI)
    • Slice thickness: 3-5mm
    • Reconstruction: Axial
    • Matrix size: Any
    • Minimum contiguous volume: Any
    • Maximum contiguous volume: Any
    • Repetition time: Shortest TR<500ms , Shortest TE<10 ms
    • Flip angle: Small FA=20º

     

    IB Diffusion

    • Image process: MR Diffusion Weighted Imaging (DWI)
    • Slice thickness: 3-5mm
    • Reconstruction: Axial
    • Matrix size: Any
    • Minimum contiguous volume: Sufficient for tumor coverage

     

    IB Neuro

    • Image process: DSC Perfusion Weighted MR Imaging (DSC-MRI)
    • Slice thickness: 3-5mm
    • Reconstruction: Axial
    • Matrix size: Any
    • Minimum contiguous volume: Sufficient for tumor coverage
    • Maximum contiguous volume: Chosen such that TR>2s with tumor coverage
    • Repetition time: 1000 – 15000ms
    • Flip angle: 60º or 30º w/preload at 1.5T 30o no preload at 3T

     

    IB Delta T1

    • Image process: MR T1-weighted images (with and without contrast)
    • Slice thickness: 3-5mm
    • Reconstruction: Axial
    • Matrix size: Any
    • Repetition time: Any
    • Flip angle: Any
    • Scanning considerations: Keep the same parameter setting for both pre and post-contrast T1

    IB DCE

    • Transfer constant from the blood plasma into the extravascular (Ktrans)
    • Extravascular, extracellular fraction of the whole tissue volume (ve)
    • Blood plasma fraction of the whole tissue volume (vp)
    • Transfer constant from the extravascular, extracellular space back to the blood plasma (kep)
    • Initial slope (IS) also known as Wash-in
    • Wash-out (WO)
    • Peak Enhancement (PE)
    • Initial Area Under the Cover (IAUC)
    • Time-to-Peak (TTP)
    • Relative Time-to-Peak (rTTP)

     

    IB Diffusion

    • Apparent Diffusion Coefficient (ADC)
    • Distributed Diffusion Coefficient (DDC)
    • Intra-voxel heterogeneity index (Alpha)

     

    IB Neuro

    • Relative Cerebral Blood Volume (rCBV)
    • Relative Cerebral Blood Flow (rCBF)
    • Mean Transit Time (MTT)
    • Time-to-Peak (TTP)
    • Relative Time-to-Peak (rTTP)
    • Percent Signal Recovery (PSR)

     

    IB Delta T1

    • Delta T1 (dT1)

      EU risk class and CE marking
      IB Clinic has CE marking and risk class I.

      Reimbursement status
      Not reimbursed.

      Contraindications
      No contraindications given.

      Target population
      Not indicated.

      Limitations
      Not Indicated.

        1.
        Instructions for Use IB Clinic, software version 2.0
        2.
        Prah MA, Al-Gizawiy MM, Mueller WM, et al Spatial discrimination of glioblastoma and treatment effect with histologically-validated perfusion and diffusion magnetic resonance imaging metrics. J Neurooncol. 2018 Jan;136(1):13-21. doi: 10.1007/s11060-017-2617-3. Epub 2017 Sep 12. PMID: 28900832; PMCID: PMC5756123.
        3.
        Hoxworth JM, Eschbacher JM, Gonzales AC, et al Performance of Standardized Relative CBV for Quantifying Regional Histologic Tumor Burden in Recurrent High-Grade Glioma: Comparison against Normalized Relative CBV Using Image-Localized Stereotactic Biopsies. AJNR Am J Neuroradiol. 2020 Mar;41(3):408-415. doi: 10.3174/ajnr.A6486. Epub 2020 Mar 12. PMID: 32165359; PMCID: PMC7077911.
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